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Mitochondrial Sirtuins as Therapeutic Targets for Age-Related Disorders

Sirtuins are a class of histone deacetylases that have a wide range of regulatory roles in the cell. Three sirtuins, SIRT3 to SIRT5, localize to and function within the mitochondria. Mitochondrial dysfunction is thought to be the underlying mechanism of several age-related diseases, such as metaboli...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shih, Jennifer, Donmez, Gizem
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: SAGE Publications 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764472/
https://ncbi.nlm.nih.gov/pubmed/24019999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912474931
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