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Mitochondrial Sirtuins as Therapeutic Targets for Age-Related Disorders
Sirtuins are a class of histone deacetylases that have a wide range of regulatory roles in the cell. Three sirtuins, SIRT3 to SIRT5, localize to and function within the mitochondria. Mitochondrial dysfunction is thought to be the underlying mechanism of several age-related diseases, such as metaboli...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
SAGE Publications
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3764472/ https://ncbi.nlm.nih.gov/pubmed/24019999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912474931 |
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