A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

We present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a “cycle of knowledge” strategy, identifying the steps with...

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Main Authors: Smallbone, Kieran, Messiha, Hanan L., Carroll, Kathleen M., Winder, Catherine L., Malys, Naglis, Dunn, Warwick B., Murabito, Ettore, Swainston, Neil, Dada, Joseph O., Khan, Farid, Pir, Pınar, Simeonidis, Evangelos, Spasić, Irena, Wishart, Jill, Weichart, Dieter, Hayes, Neil W., Jameson, Daniel, Broomhead, David S., Oliver, Stephen G., Gaskell, Simon J., McCarthy, John E.G., Paton, Norman W., Westerhoff, Hans V., Kell, Douglas B., Mendes, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science B.V 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764422/
https://ncbi.nlm.nih.gov/pubmed/23831062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.06.043
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