A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

We present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a “cycle of knowledge” strategy, identifying the steps with...

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Hlavní autoři: Smallbone, Kieran, Messiha, Hanan L., Carroll, Kathleen M., Winder, Catherine L., Malys, Naglis, Dunn, Warwick B., Murabito, Ettore, Swainston, Neil, Dada, Joseph O., Khan, Farid, Pir, Pınar, Simeonidis, Evangelos, Spasić, Irena, Wishart, Jill, Weichart, Dieter, Hayes, Neil W., Jameson, Daniel, Broomhead, David S., Oliver, Stephen G., Gaskell, Simon J., McCarthy, John E.G., Paton, Norman W., Westerhoff, Hans V., Kell, Douglas B., Mendes, Pedro
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science B.V 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764422/
https://ncbi.nlm.nih.gov/pubmed/23831062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.06.043
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