Administration of E2 and NS1 siRNAs Inhibit Chikungunya Virus Replication In Vitro and Protects Mice Infected with the Virus

BACKGROUND: Chikungunya virus (CHIKV) has reemerged as a life threatening pathogen and caused large epidemics in several countries. So far, no licensed vaccine or effective antivirals are available and the treatment remains symptomatic. In this context, development of effective and safe prophylactic...

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Bibliographic Details
Main Authors: Parashar, Deepti, Paingankar, Mandar S., Kumar, Satyendra, Gokhale, Mangesh D., Sudeep, A. B., Shinde, Sapana B., Arankalle, V. A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764232/
https://ncbi.nlm.nih.gov/pubmed/24040429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002405
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