Administration of E2 and NS1 siRNAs Inhibit Chikungunya Virus Replication In Vitro and Protects Mice Infected with the Virus

BACKGROUND: Chikungunya virus (CHIKV) has reemerged as a life threatening pathogen and caused large epidemics in several countries. So far, no licensed vaccine or effective antivirals are available and the treatment remains symptomatic. In this context, development of effective and safe prophylactic...

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Detalhes bibliográficos
Main Authors: Parashar, Deepti, Paingankar, Mandar S., Kumar, Satyendra, Gokhale, Mangesh D., Sudeep, A. B., Shinde, Sapana B., Arankalle, V. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764232/
https://ncbi.nlm.nih.gov/pubmed/24040429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002405
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