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Genome Analysis of a Transmissible Lineage of Pseudomonas aeruginosa Reveals Pathoadaptive Mutations and Distinct Evolutionary Paths of Hypermutators

Genome sequencing of bacterial pathogens has advanced our understanding of their evolution, epidemiology, and response to antibiotic therapy. However, we still have only a limited knowledge of the molecular changes in in vivo evolving bacterial populations in relation to long-term, chronic infection...

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Auteurs principaux: Marvig, Rasmus Lykke, Johansen, Helle Krogh, Molin, Søren, Jelsbak, Lars
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764201/
https://ncbi.nlm.nih.gov/pubmed/24039595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003741
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