An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression

Functional characterization of causal variants present on risk haplotypes identified through genome-wide association studies (GWAS) is a primary objective of human genetics. In this report, we evaluate the function of a pair of tandem polymorphic dinucleotides, 42 kb downstream of the promoter of TN...

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Bibliographic Details
Main Authors: Wang, Shaofeng, Wen, Feng, Wiley, Graham B., Kinter, Michael T., Gaffney, Patrick M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764111/
https://ncbi.nlm.nih.gov/pubmed/24039598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003750
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