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Regulation of Hippocampal cGMP Levels as a Candidate to Treat Cognitive Deficits in Huntington’s Disease

Huntington’s disease (HD) patients and mouse models show learning and memory impairment associated with hippocampal dysfunction. The neuronal nitric oxide synthase/3',5'-cyclic guanosine monophosphate (nNOS/cGMP) pathway is implicated in synaptic plasticity, and in learning and memory proc...

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Hlavní autoři: Saavedra, Ana, Giralt, Albert, Arumí, Helena, Alberch, Jordi, Pérez-Navarro, Esther
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764028/
https://ncbi.nlm.nih.gov/pubmed/24040016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073664
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