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The Next Generation of Transcription Factor Binding Site Prediction

Finding where transcription factors (TFs) bind to the DNA is of key importance to decipher gene regulation at a transcriptional level. Classically, computational prediction of TF binding sites (TFBSs) is based on basic position weight matrices (PWMs) which quantitatively score binding motifs based o...

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Bibliographic Details
Main Authors: Mathelier, Anthony, Wasserman, Wyeth W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764009/
https://ncbi.nlm.nih.gov/pubmed/24039567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003214
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