PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells

BACKGROUND: PAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted...

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Detalhes bibliográficos
Main Authors: Smida, Michal, Cammann, Clemens, Gurbiel, Slavyana, Kerstin, Nadja, Lingel, Holger, Lindquist, Sabine, Simeoni, Luca, Brunner-Weinzierl, Monika C, Suchanek, Miloslav, Schraven, Burkhart, Lindquist, Jonathan A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763844/
https://ncbi.nlm.nih.gov/pubmed/23601194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-28
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