RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases

Previously, we hypothesized that an RNA-based pathogenic pathway has a causal role in the dominantly inherited unstable expanded repeat neurodegenerative diseases. In support of this hypothesis we, and others, have characterized rCAG.rCUG(100) repeat double-strand RNA (dsRNA) as a previously unident...

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Detalhes bibliográficos
Main Authors: Richards, Robert I., Samaraweera, Saumya E., van Eyk, Clare L., O’Keefe, Louise V., Suter, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763583/
https://ncbi.nlm.nih.gov/pubmed/24046729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2013.00025
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