Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs

Recent evidence supports a role for RNA as a common pathogenic agent in both the ‘polyglutamine’ and ‘untranslated’ dominant expanded repeat disorders. One feature of all repeat sequences currently associated with disease is their predicted ability to form a hairpin secondary structure at the RNA le...

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Main Authors: van Eyk, Clare L., O'Keefe, Louise V., Lawlor, Kynan T., Samaraweera, Saumya E., McLeod, Catherine J., Price, Gareth R., Venter, Deon J., Richards, Robert I.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118759/
https://ncbi.nlm.nih.gov/pubmed/21518731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr177
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