Exposure to Cigarette Smoke Condensate Reduces Calcium Activated Chloride Channel Transport in Primary Sinonasal Epithelial Cultures

BACKGROUND: The cystic fibrosis transmembrane conductance regulator (CFTR) serves as a predominant Cl(−) transport conduit in airway epithelium and is inhibited by cigarette smoke in vitro and in vivo. Activation of secondary Cl(−) transport pathways through calcium-activated Cl(−) channels (CaCC) h...

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Main Authors: Virgin, Frank W., Azbell, Christopher, Schuster, Daniel, Sunde, Jumin, Zhang, Shaoyan, Sorscher, Eric J., Woodworth, Bradford A.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763501/
https://ncbi.nlm.nih.gov/pubmed/20564721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.20930
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