CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex

In the lymph node (LN) environment, chronic lymphocytic leukemia (CLL) cells display increased NF-κB activity compared with peripheral blood CLL cells, which contributes to chemoresistance. Antagonists of cellular inhibitor of apoptosis proteins (cIAPs) can induce apoptosis in various cancer cells i...

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Detalhes bibliográficos
Main Authors: Maas, C, Tromp, J M, van Laar, J, Thijssen, R, Elias, J A, Malara, A, Krippner-Heidenreich, A, Silke, J, van Oers, M HJ, Eldering, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763465/
https://ncbi.nlm.nih.gov/pubmed/23990022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.305
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