Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide

Glioblastomas (GBMs) are devastating tumors of the central nervous system, with a poor prognosis of 1-year survival. This results from a high resistance of GBM tumor cells to current therapeutic options, including etoposide (VP-16). Understanding resistance mechanisms may thus open new therapeutic a...

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Bibliographische Detailangaben
Hauptverfasser: Biasoli, D, Kahn, S A, Cornélio, T A, Furtado, M, Campanati, L, Chneiweiss, H, Moura-Neto, V, Borges, H L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763445/
https://ncbi.nlm.nih.gov/pubmed/23949216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.283
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