Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124

The methyl donors folate (vitamin B9) and vitamin B12 are centrepieces of the one-carbon metabolism that has a key role in transmethylation reactions, and thus in epigenetic and epigenomic regulations. Low dietary intakes of folate and vitamin B12 are frequent, especially in pregnant women and in th...

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Detalhes bibliográficos
Main Authors: Kerek, R, Geoffroy, A, Bison, A, Martin, N, Akchiche, N, Pourié, G, Helle, D, Guéant, J-L, Bossenmeyer-Pourié, C, Daval, J-L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763440/
https://ncbi.nlm.nih.gov/pubmed/23928694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.278
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