Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice

In the peripheral blood leukocytes (PBLs) from the carriers of the human T-lymphotropic virus type-1 (HTLV-1) or the patients with adult T-cell leukemia (ATL), nuclear factor kappaB (NF-κB)-mediated antiapoptotic signals are constitutively activated primarily by the HTLV-1-encoded oncoprotein Tax. T...

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Detalhes bibliográficos
Main Authors: Ikebe, E, Kawaguchi, A, Tezuka, K, Taguchi, S, Hirose, S, Matsumoto, T, Mitsui, T, Senba, K, Nishizono, A, Hori, M, Hasegawa, H, Yamada, Y, Ueno, T, Tanaka, Y, Sawa, H, Hall, W, Minami, Y, Jeang, K T, Ogata, M, Morishita, K, Fujisawa, J, Iha, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763384/
https://ncbi.nlm.nih.gov/pubmed/23955587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.30
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