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Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells

Mouse mammary epithelial cells undergo transdifferentiation via epithelial-mesenchymal transition (EMT) upon treatment with matrix metalloproteinase-3 (MMP3). In rigid microenvironments, MMP3 upregulates expression of Rac1b, which translocates to the cell membrane to promote induction of reactive ox...

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Autors principals: Chen, Qike K., Lee, KangAe, Radisky, Derek C., Nelson, Celeste M.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762919/
https://ncbi.nlm.nih.gov/pubmed/23660532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diff.2013.03.003
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