Directed Evolution of Mycobacterium tuberculosis β-Lactamase Reveals Gatekeeper Residue That Regulates Antibiotic Resistance and Catalytic Efficiency

Directed evolution can be a powerful tool for revealing the mutational pathways that lead to more resistant bacterial strains. In this study, we focused on the bacterium Mycobacterium tuberculosis, which is resistant to members of the β-lactam class of antibiotics and thus continues to pose a major...

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Main Authors: Feiler, Christian, Fisher, Adam C., Boock, Jason T., Marrichi, Matthew J., Wright, Lori, Schmidpeter, Philipp A. M., Blankenfeldt, Wulf, Pavelka, Martin, DeLisa, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762836/
https://ncbi.nlm.nih.gov/pubmed/24023821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073123
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