Directed Evolution of Mycobacterium tuberculosis β-Lactamase Reveals Gatekeeper Residue That Regulates Antibiotic Resistance and Catalytic Efficiency

Directed evolution can be a powerful tool for revealing the mutational pathways that lead to more resistant bacterial strains. In this study, we focused on the bacterium Mycobacterium tuberculosis, which is resistant to members of the β-lactam class of antibiotics and thus continues to pose a major...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Feiler, Christian, Fisher, Adam C., Boock, Jason T., Marrichi, Matthew J., Wright, Lori, Schmidpeter, Philipp A. M., Blankenfeldt, Wulf, Pavelka, Martin, DeLisa, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762836/
https://ncbi.nlm.nih.gov/pubmed/24023821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073123
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados