Directed Evolution of Mycobacterium tuberculosis β-Lactamase Reveals Gatekeeper Residue That Regulates Antibiotic Resistance and Catalytic Efficiency

Directed evolution can be a powerful tool for revealing the mutational pathways that lead to more resistant bacterial strains. In this study, we focused on the bacterium Mycobacterium tuberculosis, which is resistant to members of the β-lactam class of antibiotics and thus continues to pose a major...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Feiler, Christian, Fisher, Adam C., Boock, Jason T., Marrichi, Matthew J., Wright, Lori, Schmidpeter, Philipp A. M., Blankenfeldt, Wulf, Pavelka, Martin, DeLisa, Matthew P.
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2013
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762836/
https://ncbi.nlm.nih.gov/pubmed/24023821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073123
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