Directed Evolution of Mycobacterium tuberculosis β-Lactamase Reveals Gatekeeper Residue That Regulates Antibiotic Resistance and Catalytic Efficiency

Directed evolution can be a powerful tool for revealing the mutational pathways that lead to more resistant bacterial strains. In this study, we focused on the bacterium Mycobacterium tuberculosis, which is resistant to members of the β-lactam class of antibiotics and thus continues to pose a major...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Feiler, Christian, Fisher, Adam C., Boock, Jason T., Marrichi, Matthew J., Wright, Lori, Schmidpeter, Philipp A. M., Blankenfeldt, Wulf, Pavelka, Martin, DeLisa, Matthew P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762836/
https://ncbi.nlm.nih.gov/pubmed/24023821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073123
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