DYRK2 Negatively Regulates Cardiomyocyte Growth by Mediating Repressor Function of GSK-3β on eIF2Bε

BACKGROUND: A prerequisite of hypertrophic response of the myocardium is an increase in protein synthesis. A central regulator of translation initiation is Eukaryotic initiation factor 2B (eIF2B). Here we assessed the hypothesis that regulation of protein synthesis via eIF2Bε is essential to cardiac...

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Detalhes bibliográficos
Main Authors: Weiss, Celine S., Ochs, Marco M., Hagenmueller, Marco, Streit, Marcus R., Malekar, Pratima, Riffel, Johannes H., Buss, Sebastian J., Weiss, Karl H., Sadoshima, Junichi, Katus, Hugo A., Hardt, Stefan E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762802/
https://ncbi.nlm.nih.gov/pubmed/24023715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070848
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