Human circulating influenza-CD4(+) ICOS1(+)IL-21(+) T cells expand after vaccination, exert helper function, and predict antibody responses

Protection against influenza is mediated by neutralizing antibodies, and their induction at high and sustained titers is key for successful vaccination. Optimal B cells activation requires delivery of help from CD4(+) T lymphocytes. In lymph nodes and tonsils, T-follicular helper cells have been ide...

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Detalhes bibliográficos
Main Authors: Spensieri, Fabiana, Borgogni, Erica, Zedda, Luisanna, Bardelli, Monia, Buricchi, Francesca, Volpini, Gianfranco, Fragapane, Elena, Tavarini, Simona, Finco, Oretta, Rappuoli, Rino, Del Giudice, Giuseppe, Galli, Grazia, Castellino, Flora
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761599/
https://ncbi.nlm.nih.gov/pubmed/23940329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311998110
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