Human circulating influenza-CD4(+) ICOS1(+)IL-21(+) T cells expand after vaccination, exert helper function, and predict antibody responses

Protection against influenza is mediated by neutralizing antibodies, and their induction at high and sustained titers is key for successful vaccination. Optimal B cells activation requires delivery of help from CD4(+) T lymphocytes. In lymph nodes and tonsils, T-follicular helper cells have been ide...

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Autori principali: Spensieri, Fabiana, Borgogni, Erica, Zedda, Luisanna, Bardelli, Monia, Buricchi, Francesca, Volpini, Gianfranco, Fragapane, Elena, Tavarini, Simona, Finco, Oretta, Rappuoli, Rino, Del Giudice, Giuseppe, Galli, Grazia, Castellino, Flora
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761599/
https://ncbi.nlm.nih.gov/pubmed/23940329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311998110
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