Competing molecular interactions of aPKC isoforms regulate neuronal polarity

Atypical protein kinase C (aPKC) isoforms ζ and λ interact with polarity complex protein Par3 and are evolutionarily conserved regulators of cell polarity. Prkcz encodes aPKC-ζ and PKM-ζ, a truncated, neuron-specific alternative transcript, and Prkcl encodes aPKC-λ. Here we show that, in embryonic h...

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Bibliographic Details
Main Authors: Parker, Sara S., Mandell, Edward K., Hapak, Sophie M., Maskaykina, Irina Y., Kusne, Yael, Kim, Ji-Young, Moy, Jamie K., St. John, Paul A., Wilson, Jean M., Gothard, Katalin M., Price, Theodore J., Ghosh, Sourav
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761571/
https://ncbi.nlm.nih.gov/pubmed/23940317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301588110
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