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Gli activation by aPKC iota/lambda regulates basal cell carcinoma growth
Basal cell carcinoma (BCC) growth requires high levels of Hedgehog (Hh) signaling through the transcription factor Gli(1). While inhibitors of membrane protein Smoothened (Smo) effectively suppress Hh signaling, early tumor resistance illustrates the need for additional downstream targets for therap...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3761364/ https://ncbi.nlm.nih.gov/pubmed/23446420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11889 |
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