Cardiac overexpression of Mammalian enabled (Mena) exacerbates heart failure in mice

Mammalian enabled (Mena) is a key regulator of cytoskeletal actin dynamics, which has been implicated in heart failure (HF). We have previously demonstrated that cardiac Mena deletion produced cardiac dysfunction with conduction abnormalities and hypertrophy. Moreover, elevated Mena expression corre...

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Autori principali: Belmonte, Stephen L., Ram, Rashmi, Mickelsen, Deanne M., Gertler, Frank B., Blaxall, Burns C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
Soggetti:
Integrative Cardiovascular Physiology and Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761341/
https://ncbi.nlm.nih.gov/pubmed/23832697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00342.2013
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