Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS

Reduced production of nitric oxide (NO) is one of the first indications of endothelial dysfunction and precedes overt cardiovascular disease. Increased expression of Arginase has been proposed as a mechanism to account for diminished NO production. Arginases consume l-arginine, the substrate for end...

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Main Authors: Elms, Shawn, Chen, Feng, Wang, Yusi, Qian, Jin, Askari, Bardia, Yu, Yanfang, Pandey, Deepesh, Iddings, Jennifer, Caldwell, Ruth B., Fulton, David J. R.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2013
Assuntos:
Vascular Biology and Microcirculation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761326/
https://ncbi.nlm.nih.gov/pubmed/23792682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00755.2012
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