Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells

BACKGROUND: Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver disease (NAFLD), the commonest cause of chronic liv...

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Detalhes bibliográficos
Main Authors: Sigala, Barbara, McKee, Chad, Soeda, Junpei, Pazienza, Valerio, Morgan, Maelle, Lin, Ching-I, Selden, Clare, Vander Borght, Sara, Mazzoccoli, Gianluigi, Roskams, Tania, Vinciguerra, Manlio, Oben, Jude A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760858/
https://ncbi.nlm.nih.gov/pubmed/24019886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072928
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