Human PPP1R26P1 Functions as cis-Repressive Element in Mouse Rb1

The human retinoblastoma gene (RB1) is imprinted; the mouse Rb1 gene is not. Imprinted expression of RB1 is due to differential methylation of a CpG island (CpG85), which is located in the pseudogene PPP1R26P1 in intron 2 of RB1. CpG85 serves as promoter for an alternative RB1 transcript, which is e...

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Bibliographic Details
Main Authors: Steenpass, Laura, Kanber, Deniz, Hiber, Michaela, Buiting, Karin, Horsthemke, Bernhard, Lohmann, Dietmar
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760807/
https://ncbi.nlm.nih.gov/pubmed/24019952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074159
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