Association of CYP3A4/5, ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen

BACKGROUND: Pharmacogenetic study of cytochrome P450 (CYP) gene CYP2D6 and tamoxifen outcomes remain controversial. Apart from CYP2D6, other drug-metabolizing enzymes and transporters also play a role in tamoxifen metabolic pathways. The aim of this study is to investigate the impact of CYP3A4/5, AB...

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Autores principales: Sensorn, Insee, Sirachainan, Ekaphop, Chamnanphon, Montri, Pasomsub, Ekawat, Trachu, Narumol, Supavilai, Porntip, Sukasem, Chonlaphat, Pinthong, Darawan
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2013
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760448/
https://ncbi.nlm.nih.gov/pubmed/24019753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S44006
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