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Opposite effects of tolcapone on amphetamine-disrupted startle gating in low vs. high COMT-expressing rat strains

BACKGROUND: Differential sensitivity to the prepulse inhibition (PPI)-disruptive effects of dopamine agonists in Sprague–Dawley (SD) vs. Long Evans (LE) rats is heritable, reflects differential activation of DA signaling, and is associated with differences in the brain expression of specific genes,...

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Detalhes bibliográficos
Main Authors: Swerdlow, Neal R., Hines, Samantha R., Herrera, Sebastian D., Weber, Martin, Breier, Michelle R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760336/
https://ncbi.nlm.nih.gov/pubmed/23567203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2013.03.015
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