Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

Epithelial-mesenchymal transition (EMT) of adherent epithelial cells to a migratory mesenchymal state has been implicated in tumor metastasis in preclinical models. To investigate its role in human cancer, we characterized EMT in circulating tumor cells (CTCs) from breast cancer patients. Rare prima...

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Hauptverfasser: Yu, Min, Bardia, Aditya, Wittner, Ben S., Stott, Shannon L., Smas, Malgorzata E., Ting, David T., Isakoff, Steven J., Ciciliano, Jordan C., Wells, Marissa N., Shah, Ajay M., Concannon, Kyle F., Donaldson, Maria C., Sequist, Lecia V., Brachtel, Elena, Sgroi, Dennis, Baselga, Jose, Ramaswamy, Sridhar, Toner, Mehmet, Haber, Daniel A., Maheswaran, Shyamala
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760262/
https://ncbi.nlm.nih.gov/pubmed/23372014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1228522
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