Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

Epithelial-mesenchymal transition (EMT) of adherent epithelial cells to a migratory mesenchymal state has been implicated in tumor metastasis in preclinical models. To investigate its role in human cancer, we characterized EMT in circulating tumor cells (CTCs) from breast cancer patients. Rare prima...

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Detalhes bibliográficos
Main Authors: Yu, Min, Bardia, Aditya, Wittner, Ben S., Stott, Shannon L., Smas, Malgorzata E., Ting, David T., Isakoff, Steven J., Ciciliano, Jordan C., Wells, Marissa N., Shah, Ajay M., Concannon, Kyle F., Donaldson, Maria C., Sequist, Lecia V., Brachtel, Elena, Sgroi, Dennis, Baselga, Jose, Ramaswamy, Sridhar, Toner, Mehmet, Haber, Daniel A., Maheswaran, Shyamala
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760262/
https://ncbi.nlm.nih.gov/pubmed/23372014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1228522
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