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A Polymorphism that Delays Fibrosis in Hepatitis C Promotes Alternative Splicing of AZIN1, Reducing Fibrogenesis

Among several single nucleotide polymorphisms (SNPs) that correlate with fibrosis progression in chronic HCV, a SNP in the antizyme inhibitor (AzI) gene is most strongly associated with slow fibrosis progression. Our aim was to identify the mechanism(s) underlying this observation by exploring the i...

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Detalhes bibliográficos
Main Authors: Paris, Andrew J., Snapir, Zohar, Christopherson, Cindy D., Kwok, Shirley Y., Lee, Ursula E., Ghiassi-Nejad, Zahra, Kocabayoglu, Peri, Sninsky, John J., Llovet, Josep M, Kahana, Chaim, Friedman, Scott L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760215/
https://ncbi.nlm.nih.gov/pubmed/21837750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24608
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