Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier

Anti-microRNA oligonucleotides (AMOs) are steric blocking antisense reagents that inhibit microRNA (miRNA) function by hybridizing and repressing the activity of a mature miRNA. First generation AMOs employed 2′-O-Methyl RNA nucleotides (2′OMe) with phosphorothioate (PS) internucleotide linkages pos...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Lennox, Kim A, Owczarzy, Richard, Thomas, Derek M, Walder, Joseph A, Behlke, Mark A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759741/
https://ncbi.nlm.nih.gov/pubmed/23982190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.46
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky