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Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier
Anti-microRNA oligonucleotides (AMOs) are steric blocking antisense reagents that inhibit microRNA (miRNA) function by hybridizing and repressing the activity of a mature miRNA. First generation AMOs employed 2′-O-Methyl RNA nucleotides (2′OMe) with phosphorothioate (PS) internucleotide linkages pos...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3759741/ https://ncbi.nlm.nih.gov/pubmed/23982190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.46 |
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