LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program

The cellular reprogramming factor LIN28A promotes tumorigenicity in cancers arising outside the central nervous system, but its role in brain tumors is unknown. We detected LIN28A protein in a subset of human gliomas observed higher expression in glioblastoma (GBM) than in lower grade tumors. Knockd...

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Bibliographische Detailangaben
Hauptverfasser: Mao, Xing-gang, Hütt-Cabezas, Marianne, Orr, Brent A., Weingart, Melanie, Taylor, Isabella, Rajan, Anand K.D., Odia, Yazmin, Kahlert, Ulf, Maciaczyk, Jarek, Nikkhah, Guido, Eberhart, Charles G., Raabe, Eric H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2013
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759665/
https://ncbi.nlm.nih.gov/pubmed/23846349
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