Lin28 Enhances Tumorigenesis and is Associated With Advanced Human Malignancies

Multiple members of the let-7 family of miRNAs are often repressed in human cancers1,2, thereby promoting oncogenesis by de-repressing the targets K-Ras, c-Myc, and HMGA2 3,4. However, the mechanism by which let-7 miRNAs are coordinately repressed is unclear. The RNA-binding proteins Lin28 and Lin28...

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Main Authors: Viswanathan, Srinivas R., Powers, John T., Einhorn, William, Hoshida, Yujin, Ng, Tony, Toffanin, Sara, O'Sullivan, Maureen, Lu, Jun, Philips, Letha A., Lockhart, Victoria L., Shah, Samar P., Tanwar, Pradeep S., Mermel, Craig H., Beroukhim, Rameen, Azam, Mohammad, Teixeira, Jose, Meyerson, Matthew, Hughes, Timothy P., Llovet, Josep M, Radich, Jerald, Mullighan, Charles G., Golub, Todd R., Sorensen, Poul H., Daley, George Q.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757943/
https://ncbi.nlm.nih.gov/pubmed/19483683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.392
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