Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock()

We have previously demonstrated that a stable synthetic analog of 20-hydroxyeicosatetraenoic acid (20-HETE), N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine (5,14-HEDGE), prevents vascular hyporeactivity, hypotension, tachycardia, and inflammation in rats treated with lipopolysaccharide (LPS) and mor...

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Autores principales: Tunctan, Bahar, Korkmaz, Belma, Sari, Ayse Nihal, Kacan, Meltem, Unsal, Demet, Serin, Mehmet Sami, Buharalioglu, C. Kemal, Sahan-Firat, Seyhan, Cuez, Tuba, Schunck, Wolf-Hagen, Manthati, Vijaya L., Falck, John R., Malik, Kafait U.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759626/
https://ncbi.nlm.nih.gov/pubmed/23684565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2013.05.001
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