Optimized S-Trityl-l-cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models

[Image: see text] The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-l-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved potency, favorable drug-like p...

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Main Authors: Good, James A. D., Wang, Fang, Rath, Oliver, Kaan, Hung Yi Kristal, Talapatra, Sandeep K., Podgórski, Dawid, MacKay, Simon P., Kozielski, Frank
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759169/
https://ncbi.nlm.nih.gov/pubmed/23394180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3014597
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