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Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity†

[Image: see text] The human mitotic kinesin Eg5 represents a novel mitotic spindle target for cancer chemotherapy. We previously identified S-trityl-l-cysteine (STLC) and related analogues as selective potent inhibitors of Eg5. We herein report on the development of a series of 4,4,4-triphenylbutan-...

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Main Authors: Wang, Fang, Good, James A. D., Rath, Oliver, Kaan, Hung Yi Kristal, Sutcliffe, Oliver B., Mackay, Simon P., Kozielski, Frank
格式: Artigo
語言:Inglês
出版: American Chemical Society 2012
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428805/
https://ncbi.nlm.nih.gov/pubmed/22248262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201195m
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