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Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity†
[Image: see text] The human mitotic kinesin Eg5 represents a novel mitotic spindle target for cancer chemotherapy. We previously identified S-trityl-l-cysteine (STLC) and related analogues as selective potent inhibitors of Eg5. We herein report on the development of a series of 4,4,4-triphenylbutan-...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428805/ https://ncbi.nlm.nih.gov/pubmed/22248262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201195m |
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