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NMR spectroscopic detection of chirality and enantiopurity in referenced systems without formation of diastereomers
Enantiomeric excess of chiral compounds is a key parameter that determines their activity or therapeutic action. The current paradigm for rapid measurement of enantiomeric excess using NMR is based on the formation of diastereomeric complexes between the chiral analyte and a chiral resolving agent,...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3759048/ https://ncbi.nlm.nih.gov/pubmed/23864041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3188 |
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