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Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells
Precise cellular targeting of macromolecular cargos has important biotechnological and medical implications. Using a recently established ‘protein stapling’ method, we linked the proteolytic domain of botulinum neurotoxin type A (BoNT/A) to a selection of ligands to target neuroendocrine tumor cells...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3758956/ https://ncbi.nlm.nih.gov/pubmed/23638840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12284 |
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