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The Intertwining of Structure and Function: Proposed Helix-Swapping of the SH2 Domain of Grb7, A Regulatory Protein Implicated in Cancer Progression and Inflammation
Grb7 is a multidomain intracellular signaling protein that links activated tyrosine kinases with downstream signaling targets. Best known for its regulatory role in cell migration and tumor metastasis, Grb7 also regulates inflammation by coupling NF-kappaB-inducing kinase with erbB/EGFR family recep...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3758479/ https://ncbi.nlm.nih.gov/pubmed/20370637 |
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