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A circadian sleep disorder reveals complexity in the clock

Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007), characterize mice expressing a human Per2 mutation identified in patients with Familial Advanced Sleep Phase Syndrome. Their results reveal that PER2...

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Autors principals: Mignot, Emmanuel, Takahashi, Joseph S.
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758472/
https://ncbi.nlm.nih.gov/pubmed/17218251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.12.024
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