The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction

Telomeres are essential for genomic integrity, but little is known about their regulation in the normal human mammary gland. We now demonstrate that a phenotypically defined cell population enriched in luminal progenitors (LPs) is characterized by unusually short telomeres independently of donor age...

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Bibliografiske detaljer
Main Authors: Kannan, Nagarajan, Huda, Nazmul, Tu, LiRen, Droumeva, Radina, Aubert, Geraldine, Chavez, Elizabeth, Brinkman, Ryan R., Lansdorp, Peter, Emerman, Joanne, Abe, Satoshi, Eaves, Connie, Gilley, David
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2013
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757746/
https://ncbi.nlm.nih.gov/pubmed/24052939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.04.003
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