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High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate

We investigated the impact of poor maternal nutrition and metabolic health on the development of islets of the nonhuman primate (NHP). Interestingly, fetal offspring of high fat diet (HFD) fed animals had normal total islet and β cell mass; however, there was a significant reduction in α cell mass,...

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Detalhes bibliográficos
Main Authors: Comstock, Sarah M., Pound, Lynley D., Bishop, Jacalyn M., Takahashi, Diana L., Kostrba, Ashley M., Smith, M. Susan, Grove, Kevin L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757659/
https://ncbi.nlm.nih.gov/pubmed/24024126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2012.11.001
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