The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

FGF21 is a multifunctional metabolic regulator. The co-factor βKlotho (KLB) allows FGF21 to signal via FGF receptors. Given the widespread nature of FGFR expression and KLB presence in several organs, it remains unclear which tissue/FGFR isoform determine FGF21 action. Here we show that deletion of...

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Autori principali: Adams, Andrew C., Yang, Chaofeng, Coskun, Tamer, Cheng, Christine C., Gimeno, Ruth E., Luo, Yongde, Kharitonenkov, Alexei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2012
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757657/
https://ncbi.nlm.nih.gov/pubmed/24024127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2012.08.007
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