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Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation

Protein translation is an energetically demanding process that must be regulated in response to changes in nutrient availability. Herein, we report that the thiolation status of wobble-uridine (U(34)) nucleotides present on lysine, glutamine or glutamate tRNAs reflects intracellular methionine and c...

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Detalhes bibliográficos
Main Authors: Laxman, Sunil, Sutter, Benjamin M., Wu, Xi, Kumar, Sujai, Guo, Xiaofeng, Trudgian, David C., Mirzaei, Hamid, Tu, Benjamin P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757545/
https://ncbi.nlm.nih.gov/pubmed/23870129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.043
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